Applications in Modeling Infectious Disease Processes

May 4th, 2014 | By | Category: Other, Systems Engineering

Applications in Modeling Infectious Disease ProcessesResearchers: Ulisses Braga-Neto

This work is part of a long-standing collaboration with Dr. Ernesto Marques’ research groups at the at the Johns Hopkins Medical School (Dr. Marques’ previous affiliation), the University of Pittsburgh’s Center for Vaccine Research, and the Oswaldo Cruz Foundation (FIOCRUZ), in Recife, Brazil. The focus of this collaboration is the application of Genomic Signal Processing methodology to the study of infectious diseases, for vaccine design, discovery of diagnostic/prognostic markers, and biodefense efforts, using data from a series of human patient cohort studies in dengue, yellow fever, hepatitis A, HIV-1, and rabis being conducted at FIOCRUZ in Brazil. Highlights of this research include identification of gene-expression, SNP, and blood-serum biomarkers for prognosis of a serious form of dengue fever, known as dengue hemorrhagic fever (DHF), and the development of a classifier for inexpensively diagnosing primary or secondary dengue infections using a single blood sample.

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