Other

Bioinformatics Jobs

Dec 25th, 2015 | By

The CBGSE’s bioinformatics jobs site lists opening bioinformatics and computational biology jobs from around the world. In the last year we have posted over 2100 open positions. In addition to posting job openings this site has allowed us to collect data an critical jobs skills need in today’s bioinformatics job market.



Dr. Peng Yu creates new database and webserver for mouse RNASeq studies

Sep 21st, 2015 | By

  Bioinformatics. 2015 Aug 30. RNASeqMetaDB: a database and web server for navigating metadata of publicly available mouse RNA-Seq datasets. Guo Z, Tzvetkova B, Bassik JM, Bodziak T, Wojnar BM, Qiao W, Obaida MA, Nelson SB, Hu BH, Yu P Abstract Gene targeting is a protocol for introducing a mutation to a specific gene in

[continue reading…]



Cancer’s Heterogeneity Modeling tumors’ diversity article

Mar 11th, 2015 | By

Cancer’s Heterogeneity Modeling tumors’ diversity By Alexander Gelfand This Cancer might spring from a single cell gone awry, but tumors are not monolithic collections of clones. Far from it: They contain many different types of cancer cells, all with their own mutations, proliferation rates, metastatic capacities, and drug responses.diversity pushes the limits of current diagnostic and

[continue reading…]



Engineering Applications in Genomics Course online

Nov 19th, 2014 | By

ECEN 669 – Engineering Applications in Genomics Taught by Dr. Aniruddha Datta             Description The aim of this course is to provide graduate students with a glimpse of the fascinating ways in which electrical engineering approaches are being used in the area of systems biology. Having taken this course, the students

[continue reading…]



Structural genomics

May 4th, 2014 | By

Researchers: Yu Peng Evolution-based methods are currently among the most successful ones in predicting protein structures. The central idea is that evolution information, derived based on protein sequences alone, can be used to guide protein folding. We are interested in developing new methods to predict protein structures using rapidly accumulating HTS data.



Metagenomics

May 4th, 2014 | By

Researchers: Yu Peng Metagenomics is the direct sequencing and analysis of microbial communities in environmental or host-constrained samples, which offers a viable way to study more than 99% of all microbes that are unculturable. But analyses of complex mixtures of organisms remain challenging. We are interested in developing new analysis methods to understand the composition and

[continue reading…]



Genomics of complex diseases

May 4th, 2014 | By

Researchers: Yu Peng Complex diseases, such as Autism Spectrum Disorders, are caused by a combination of genetic and environmental factors. The non-Mendelian inheritance pattern of these diseases has defeated attempts to predict the occurrence of these diseases based on genomic information. We address this challenge by developing novel computational methods using systems biology approaches such as

[continue reading…]



Regulation of gene expression

May 4th, 2014 | By

Researchers: Yu Peng Eukaryote gene expression is tightly controlled to give arise to different cell types and tissues. To understand transcription regulation, we develop new computational methods by integrating ChIP-seq, DNA methylation, nucleosome positioning, CLIP-seq and RNA-seq data. We closely work with experimental biologists to validate our predictions.



Statistical HTS data analysis

May 4th, 2014 | By

Researchers: Yu Peng High-throughput sequencing technologies are widely used in biology experiments. These experiments typically have few biological replicates because of, for example, budget and time constraints. Our lab develops powerful and statistical rigorous methods to maximally extract information from these experiments that would otherwise not be possible.



Applications in Modeling Infectious Disease Processes

May 4th, 2014 | By

Researchers: Ulisses Braga-Neto This work is part of a long-standing collaboration with Dr. Ernesto Marques’ research groups at the at the Johns Hopkins Medical School (Dr. Marques’ previous affiliation), the University of Pittsburgh’s Center for Vaccine Research, and the Oswaldo Cruz Foundation (FIOCRUZ), in Recife, Brazil. The focus of this collaboration is the application of Genomic

[continue reading…]