Postdoctoral Fellow in Bioinformatics and Lymphoma Genomics : Vancouver, Canada

Job ID: 595831
Job date: 2016-11-10

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Job Description:
The British Columbia Cancer Agency is seeking a Postdoctoral Fellow to conduct scientific research in the area of cancer genomics specifically related to an ongoing effort to understand the aetiology of aggressive lymphoid cancers including diffuse large B-cell and mantle cell lymphomas. The successful applicant will analyze NGS data produced from clinical samples from cancer patients, namely RNA-seq, whole exome, whole genome, and circulating tumour DNA sequence data. This position demands a strong bioinformatics and genomics background. Detailed knowledge of cancer biology (particularly non-Hodgkin lymphomas) would be an asset. Familiarity with algorithms for inferring clonal structure of tumours from sequence data and network/pathway analysis methods is also desirable. Characteristics of the ideal candidate include strong verbal and written communication skills, attention to detail, creativity and the ability to remain organized in a fast-paced and dynamic environment. The successful candidate will report to Drs. Ryan Morin (Genome Sciences Centre, BCCA) and David Scott (Centre for Lymphoid Cancer, BCCA) and will interact with a diverse team of clinicians and research scientists at the BC Cancer Agency. Typical duties will include the following:

  • Use alignment and assembly-based methods to detect somatic alterations such as CNAs, SNVs, indels and structural alterations/fusion transcripts.
  • Implement improved algorithms/pipelines for detection of somatic alterations in heterogeneous tumour samples and damaged DNA (FFPE, ctDNA)
  • Infer novel driver genes and pathways using recurrence-based and selective-pressure based methodologies
  • Resolve clonal frequency of mutations and clonal substructure of tumours
  • Delineate clonal dynamics from serial tumour biopsies and ctDNA
  • Determine significant changes to gene expression and splicing
  • Leverage clinical metadata to identify predictive or prognostic signatures
Suitable candidates should possess a PhD degree in molecular biology or bioinformatics. Applicants: please upload a merged document containing a CV and cover letter to the link provided. You may also send these documents by email to rdmorin@sfu.ca if necessary. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority. Duration: 2 years (possibility of extension). Salary will be commensurate with experience and competitive.…


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