Principal Scientist, Biologics Discovery Job – Merck – Palo Alto, CA

Oct 10th, 2016 | By | Category:
Job ID: 6054
Job date: 2016-10-07
End Date:

Company : Merck 

Country :

Role : Research Scientist 

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Job Description:
Principal Scientist, Biologics Discovery-BIO004534


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

The Biologics Discovery, DMPK and Disposition function at MRL, Palo Alto focuses strongly on the application of computational biology, systems pharmacology and quantitative principles during the discovery and early development for biologics in an integrated fashion

The position will be a critical and senior member of the function providing strong expertise necessary for development of:

The central core modeling and quantitative expertise for the Department. The modeling efforts will be in support of projects related to: Drug and combination therapeutic concepts and dose predictions for the design and conduct of preclinical efficacy and nonclinical safety studies Computational biology and systems pharmacology principles in order to establish and build predictive preclinical drug combination frameworks with application in various therapeutic areas Mechanistic approaches (and in an integrated fashion) for integration of key properties such as-- target expression, gene profiles, signaling and pathways, construct properties, disease considerations-- for establishing exposure-response relationships in relevant preclinical studies and assisting in projection of doses in early human clinical studies in support of IND submissions. Network analysis and application of bioinformatics principles in data mining and evaluation/interpretation of complex biological systems Independently managing functional deliverables, collaborating with the senior PK/PD scientists for implementation of advanced quantitative approaches in support of nonclinical development of various projects (from discovery to FIH studies). Collaborates and coordinates extensively and effectively across functions and both internally and externally to achieve program deliverables as part of a team. Management experience is required Qualifications

PhD. In Computational Biology, Biomedical Engineering, Mathematical Sciences with focus on Biostatistics, Pharmaceutical Sciences, Biochemical Engineering with strong background in quantitative sciences and systems approaches Required:
Minimum of 8 years of combined industry and/or postdoctoral experience in relevant field with strong focus on application of quantitative sciences in drug and biologics development Strong experience in PK-PD modeling, simulations and application of biostatistics and PK-PD approaches Strong communication, managerial experience, writing skills and ability to function in a highly team-oriented environment Background and familiarity with the fundamentals of pharmacology, physiology and basic principles of drug actions, and the drug development process Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

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Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Visa sponsorship is not available for this position.

For more information about personal rights under Equal Employment Opportunity, visit:

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job: Biology-Discovery

Job Title: Prin. Scientist, Biology-Discovery

Primary Location: NA-US-CA-Palo Alto

Other Locations: NA-US-MA-Boston

Employee Status: Regular

Travel: Yes, 5 % of the Time

Number of Openings: 1

Shift (if applicable): 1st

Company Trade Name: Merck

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