RESEARCH FELLOW – Massachusetts General Hospital(MGH) – Cambridge, MA

Job ID: 6100
Job date: 2016-10-16

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Job Description:
Employing Hospital and Department:
Ragon Institute of MGH, MIT, and Harvard

Minimum degree and field of knowledge: PhD, MD
Years experience required: 0 – 2 years experience

Summary:
The Ragon Institute of MGH, MIT and Harvard located in Kendall Square in Cambridge, MA has an opening in the Allen laboratory ( http://www.ragoninstitute.org/portfolio-item/allen-lab/ ) for a highly motivated postdoctoral fellow to study the role of HIV sequence evolution in the development of broadly neutralizing antibodies.
This position requires a Ph.D. or an M.D. with a background in humoral immunity, evolutionary biology, and/or bioinformatics. Research will focus on elucidating the role that viral evolution and escape from humoral immune responses plays in the development and maturation of broadly neutralizing antibodies to HIV. Efforts will include application of next generation sequencing (NGS) technologies to address these questions and development of advanced comparative genomic tools for the analysis of large viral genomic NGS datasets.
Goals are to understand the role of HIV sequence evolution in the development of broadly neutralizing antibodies and apply this knowledge to design the effective components of an HIV vaccine.
State-of-the-art facilities are available within an exceptionally energetic research setting.

Job Duties:
Under the direction of the principal investigator the applicant independently carries out daily activities of the laboratory.
Performs molecular biology and cell-based assays utilizing standard techniques (DNA/RNA extraction and analysis, standard and quantitative PCR, site-directed mutagenesis, neutralization assays, ELISAs)
Next-generation Illumina library construction and sequencing
Bioinformatic analysis of conventional bulk and next-generation sequence data
Develop a dvanced comparative genomic tools for the analysis of large viral genomic NGS datasets
Detailed documentation of the experimental work

Qualifications
Qualifications: A Ph.D. or M.D. with relevant experience in humoral immunity, evolutionary biology, and/or bioinformatics. Strong candidates will have demonstrated experience in the immunology or virology of infectious diseases and/or experience with NGS analysis and phylogenetic tools. Candidates must be highly motivated and independent, with the ability to work in a dynamic team environment. Good organizational skills and excellent attention to detail Ability to perform as a team member and must have good interpersonal skills EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Primary Location : MA-Cambridge-400 Technology - MGH

Work Locations : 400 Technology - MGH
400 Technology Square
Cambridge 02139

Job : MD/PHD/Fellows/ PostDocs
Organization : Massachusetts General Hospital(MGH)
Schedule : Full-time
Standard Hours : 40
Shift : Day Job

Employee Status : Regular
Recruiting Department : MGH AIDS Research Center
Job Posting : Oct 3, 2016


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