Biomarker development: Prudence, risk, and reproducibility

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Type: Journal Publication


Abstract: In searching for biomarkers, one might maintain that it is prudent to have preliminary studies based on small samples. Given a satisfactory result, a large-sample follow-on study can then check reproducibility. However, is this two-fold approach, namely the decision to conduct the small study and the subsequent decision to spend significant resources on a large study, actually prudent? There is the risk that in the first study nothing at all might be discovered while in the second study the first results are not reproducible

Cited as: Dougherty, E. R., "Biomarker development: Prudence, risk, and reproducibility", BioEssays, Vol. 34, No. 4, 277-279, 2012

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