Identification of Druggable Hot Spots on Proteins and in Protein–Protein Interfaces

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Type: Book Chapter


Abstract: The interactions of proteins with each other and other biochemical compounds play a central role in various aspects of the structural and functional organization of the cell. Elucidation of such interactions is a major step toward understanding cellular pathways and processes and also suggests avenues for drug design. One observation that emerges from these studies is that the various residues in the binding region do not equally contribute to the binding free energy


Cited as: Dmitri Beglov, Ryan Brenke, Gwo-Yu Chuang, David Hall, Melissa Landon, Chi Ho Ngan, Yang Shen, Spencer Thiel, Brandon Zerbe, Dima Kozakov, Sandor Vajda, "Identification of Druggable Hot Spots on Proteins and in Protein–Protein Interfaces", In D Beglov, R Brenke, GY Chuang, D Hall, M Landon eds., Computational Protein-Protein Interactions, 2010, CRC Press

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