Type: Journal Publication
Abstract: For science, theoretical or applied, to significantly advance, researchers must use the most appropriate mathematical methods. A century and a half elapsed between Newton’s development of the calculus and Laplace’s development of celestial mechanics. One cannot imagine the latter without the former. Today, more than three-quarters of a century has elapsed since the birth of stochastic systems theory. This article provides a perspective on the utilization of systems theory as the proper vehicle for the development of systems biology and its application to complex regulatory diseases such as cancer.
Cited as: Bittner, M. L., and Dougherty, E. R., "Newton, Laplace, and the Epistemology of Systems Biology", Cancer Informatics, 2012:5, 185-190